FREQUENCY OF DIABETES MELLITUS IN PATIENTS WITH CHRONIC LIVER DISEASE

Abstract

Background & Summary: The liver is essential and crucial in regulating carbohydrate metabolism and Gluconeogenesis. Its normal function is necessary for maintaining glucose levels in the blood and supplying energy to organs. Several hormones, including insulin, glucagon, growth hormone, cortisol, and catecholamine, contribute to the regulation of glucose metabolism by the liver. This leading role of the liver in glucose homeostasis gives us a clue to the pathogenesis of glucose intolerance or Diabetes in liver diseases. There is a strong correlation between diabetes mellitus and liver diseases: several glucose metabolism alterations are commonly found in subjects with chronic liver disease. The pathogenesis of impaired glucose metabolism during chronic liver disease has not yet been fully understood. Objective: The current study's objective was to determine the frequency of Diabetes mellitus in chronic liver patients. Methodology: It was a descriptive study. A total of 89 samples from patients with chronic liver disease were collected from the tertiary care Hospital of Lahore. 5 CC blood samples were drawn from the anti-cubital vein according to proper phlebotomy protocol and then dispensed in a vial with anticoagulant sodium fluoride for glucose estimation and a vial with anticoagulant EDTA for HbA1c. Results: Out of these 89 samples, 49 (55.1 %) were males & 40 (44.9%) were Females. According to our results, the frequency of present Diabetes in chronic liver patients is 61.8%. Conclusion: This study concluded that the frequency of Diabetes in chronic liver patients is 61.8%, which is statistically significant. Early analysis of Diabettes, and HbA1c levels, can be utilized as a preventive measure for glycemic control.